5-amino-1MQ is a small molecule drug whose primary function is to block the activity of an enzyme called Nicotinamide N-Methyltransferase (NNMT). Nicotinamide N-methyltransferase (NNMT) has been implicated in several diseases such as osteoarthritis, insuline resistance, metabolic disorders, cardiovascular disease, cancer, obesity, kidney disease, and Parkinson's disease. Higher NNMT expression and MNA concentrations trigger the downstream signaling leading to insuline resistance and supplementing with 5-Amino-1-Methylquinoline blocks this from taking place resulting in weight loss at preserved food intake on a high-fat diet.
