BPC 157 (Corpus Praesidium Compositum-157) XV-amino acid pentapeptide est. Sequentia amino acidorum in BPC 157 amino acido BPC humano. Acidum gastricum in humano BPC inventum. Experimenta demonstrant vulnus sanationis augere posse BPC157, inter vulnera tendinis, ut rat tendinis Achillis traduci. Finis huius studii erat investigare machinationes possibilis quibus BPC 157 est ad accelerandum sanationis laesae tendinum. Studium usus est duabus tendinis explantationibus, one of which was cultured in BPC157-containing medium and the other was cultured in a medium lacking BPC 157.
Insuper, FITC-phalloidin staining demonstrated that BPC157 induced F-actin formation in fibroblasts. similiter, Western blot analysis was able to detect the production and activation of pudding proteins and FAK proteins. Western blot analysis also showed that BPC157 increased the phosphorylation of puerarin and FAK protein without affecting the amount produced.
FITC-phalloidin staining demonstrated that BPC157 induced F-actin formation in fibroblasts. similiter, Western blot analysis was able to detect the production and activation of pudding proteins and FAK proteins. Western blot analysis also showed that BPC157 increased the phosphorylation of puerarin and FAK protein without affecting the amount produced.
BPC 157 has a strong antiinflammatory activity in acute and chronic inflammatory models and may be an important treatment for the treatment of inflammatory bowel disease. BPC 157 shows accelerated wound healing and has significant angiogenesis. But also significantly promote the healing of rat fractures, showing osteogenesis, significantly improve the healing of segmental bone defects.BPC 157 rat tendinis Achillis musculi quadriceps, significantly acceleravit tendinis incrementum plantarum. Proliferatio tendinis Achillis myofibroblastae e tendinis culturae fibroblastarum MTT deductis non directe a BPC affectus est. 157.
Experimenta videre eventus cum orali, peritonaei, et situm infundi. 10 micrograms per kg erat dose in muribus illis proventibus. Id oris vel iniectio nihil interest, cum exigua sanationis huius sors tota fit facilior.
