1.It has been used in the treatment of cerebral salt wasting.
2.It is used primarily to replace the missing hormone aldosterone in various forms of adrenal insufficiency such as Addison's disease and the classic salt wasting (21-hydroxylase deficiency) form of congenital adrenal hyperplasia.
3.It is the first line of treatment for orthostatic intolerance as well.
4.It is also a confirmation test for diagnosing Conns Syndrome (Aldosterone producing-Adrenal adenoma), the fludrocortisone suppression test. Încărcarea pacientului cu fludrocortizon ar suprima nivelul seric de aldosteron la un pacient normal, întrucât nivelul nu va fi modificat la un pacient Conns.
