L-5-Methyltetrahydrofolate calcium 151533-22-1 is a naturally occurring salt forming methyl derivative of folate. 5-mthf, also known as l-methylfolate, is the most biologically active and functional form of folate and is more easily absorbed than folate.Common folate must be converted to l-methylfolate in order to participate in the two main metabolic pathways: methylation and DNA synthesis. The only form of free folate present in human plasma and cells is 5-mthf.Deficiency of folic acid is usually caused by insufficient absorption due to vitamin deficiency. Folic acid needs to be increased during pregnancy and breast-feeding, as well as during childhood growth. Folate-rich food cannot guarantee the dose provided by absorption or metabolic changes or drugs, so it needs to be supplemented.
1. L-5-MTHF Ca is Mainly for folic acid antagonists (such as methotrexate, pyrimethamine, benzyl cefalexin and trimethoprim) antidote, it's usually used for prevention of methotrexate dose or overdose treatment caused severe toxic effects.
2. L-5-MTHF Ca is used for Folic acid treatment of the following diseases, such as inflammatory diarrhea
and protein-energy malnutrition (poor nutrition), pregnancy or infancy megaloblastic anemia caused by poor.
3. L-5-MTHF Ca as adjuvant therapy for colon cancer, rectal cancer.
4. Combined with 5-FU and treatment of digestive tract tumors or other 5-FU-sensitive tumors.High-dose CF used in conjunction with 5-FU (LF), the basic programme is currently the treatment of colon and rectal cancer.
5. L-5-MTHF Ca is used For children with leukemia, lymphoma, and osteosarcoma, such as high dose MTX treatment when rescued.
