Toripristone (ГОСТИНИЦА) (developmental code name RU-40555) является синтетическим, steroidal antiglucocorticoid as well as antiprogestogen which was never marketed.It is reported as a potent and highly selective antagonist of the glucocorticoid receptor (GR) (Ki = 2.4 нМ),though it also acts as an antagonist of the progesterone receptor (пиар).The pharmacological profile of toripristone is said to be very similar to that of mifepristone, except that toripristone does not bind to orosomucoid (α1-acid glycoprotein).Препарат использовался для изучения гипоталамо-гипофизарно-надпочечниковой оси и использовался в качестве радиофармпрепарата для ГР. Его МНН указано в 1990
