[ Последовательность ] Ac-D-2-Nal-D-4-Cl-Phe-D-3-Pal-Ser-N-Me-Tyr-D-Asn-Leu-Lys(ipr)-Pro-D-Ala-NH2
[ Синонимы ] PPI 149 acetate; Plenaxis;Abarelix
[ № КАС. ] 183552-38-7
[ Молекулярная формула ] C74H99ClN14O16
[ Молекулярный вес ] 1476.138
[ Плотность ] 1.287 г/см3
[ Точка кипения ] 1688.37 °С при 760 мм рт.ст.
[ Точка возгорания ] 974.891 °С
[ Появление ] Белый порошок
[ Приложение ] Active Pharmaceutical Ingredients
[ Чистота ] 98%
[ Main Function ]
Scientific research only, no direct use for human body
Abarelix is a synthetic decapeptide and antagonist of naturally occurring gonadotropin-releasing hormone (ГнРГ). Abarelix directly and competitively binds to and blocks the gonadotropin releasing hormone receptor in the anterior pituitary gland, thereby inhibiting the secretion and release of luteinizing hormone (ЛГ) and follicle stimulating hormone (ФСГ). In males, the inhibition of LH secretion prevents the release of testosterone. As a result, this may relieve symptoms associated with prostate hypertrophy or prostate cancer, since testosterone is required to sustain prostate growth.
Abarelix Acetate is an injectable gonadotropin-releasing hormone antagonist (GnRH antagonist). Abarelix Acetate is primarily used in oncology to reduce the amount made in patients with advanced symptomatic prostate cancer for which no other treatment options are available.
