[ دنباله ] Ac-D-2-Nal-D-4-Cl-Phe-D-3-Pal-Ser-N-Me-Tyr-D-Asn-Leu-Lys(ipr)-Pro-D-Ala-NH2
[ مترادف ها ] PPI 149 استات; Plenaxis;آباریکس
[ CAS NO. ] 183552-38-7
[ فرمول مولکولی ] C74H99ClN14O16
[ وزن مولکولی ] 1476.138
[ تراکم ] 1.287 g/cm3
[ نقطه جوش ] 1688.37 درجه سانتی گراد در 760 میلی متر جیوه
[ نقطه فلاش ] 974.891 درجه سانتی گراد
[ ظاهر ] پودر سفید
[ کاربرد ] مواد فعال دارویی
[ خلوص ] 98%
[ عملکرد اصلی ]
Scientific research only, no direct use for human body
Abarelix is a synthetic decapeptide and antagonist of naturally occurring gonadotropin-releasing hormone (GnRH). Abarelix directly and competitively binds to and blocks the gonadotropin releasing hormone receptor in the anterior pituitary gland, thereby inhibiting the secretion and release of luteinizing hormone (LH) و هورمون محرک فولیکول (FSH). در مردان, the inhibition of LH secretion prevents the release of testosterone. در نتیجه, this may relieve symptoms associated with prostate hypertrophy or prostate cancer, since testosterone is required to sustain prostate growth.
Abarelix Acetate is an injectable gonadotropin-releasing hormone antagonist (آنتاگونیست GnRH). Abarelix Acetate is primarily used in oncology to reduce the amount made in patients with advanced symptomatic prostate cancer for which no other treatment options are available.
