Dexamethasone palmitate (DXP) is a lipophilic prodrug of dexamethasone (DXM), a potent corticosteroide used to treat a variety of ophthalmic diseases. The aim of the study was to characterize the sustained release capacity (in rabbit), efficacy (in rat and rabbit), and safety (in rabbit, cat, and minipig) of intravitreal (IVT) DXP emulsions in preclinical models.
Dexamethasone palmitate (DXP) är en prodrug av Dexametason, som är en glukokortikoidreceptoragonist. Dexamethasone palmitate (DXP) har 47 gånger lägre affinitet för glukokortikoidreceptorn än dexametason. Antiinflammatoriskt medel.
