La elamipretida es un tetrapéptido catiónico aromático que penetra fácilmente las membranas celulares y se localiza transitoriamente en la membrana mitocondrial interna, donde se asocia con la cardiolipina.. A través de este mecanismo de acción, Se cree que la elamipretida restablece la producción de energía., para reducir la producción de especies reactivas de oxígeno, y en última instancia aumentar la energía (trifosfato de adenosina [atp]) supplied to affected cells and organs.In preclinical studies, elamipretide increased the synthesis of ATP and reduced reactive oxygen species production regardless of the specific mitochondrial abnormality causing the impaired mitochondrial respiration.There is no observed effect on normally functioning mitochondria.
elamipretida (also known as SS-31, , MTP-131 and Bendavia) is a small mitochondrially-targeted tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that appears to reduce the production of toxic reactive oxygen species and stabilize cardiolipin.
Stealth Peptides, a privately held company, was founded in 2006 to develop intellectual property licensed from several universities including elamipretide; it subsequently changed its name to Stealth BioTherapeutics.
Nombre del producto :elamipretida
Sinónimos: SS-31, MTP-131, Bendavia, RX-31
CAS#: 736992-21-5
Fórmula molecular: do32h49norte9oh5
megavatio: 639.79
Secuencia:H-D-Arg-(2´,6´-dimethyl-Tyr)-Lys-Phe-NH2
Apariencia: polvo blanco
Pureza (HPLC):≥98,0%
Impureza única (HPLC): ≤2,0%
Contenido de acetato(HPLC): 5.0%-12.0%
Contenido de agua (Karl Fischer): ≤10,0%
Contenido de péptidos: ≥80,0%
