Megestrol acetate (GOSTILNA, USAN, PREPOVED, JAN) (abbreviated as MGA or MA, and sold mainly under the brand names Megace and Megace ES), also known as 17α-acetoxy-6-dehydro-6-methylprogesterone, is a steroidal progestin and progesterone derivative (posebej, a 17-hydroxylated progesterone) with predominantly progestational and antigonadotropic effects.
(1). Mainly used for short-acting oral contraceptives, also can be used for intramuscular injection of long-acting contraceptives.
(2). For the treatment of dysmenorrhea, amenoreja, disfunkcionalna krvavitev iz maternice, endometrioza in adenokarcinom endometrija.
(3).Megestrol acetat se uporablja predvsem kot stimulans apetita pri različnih stanjih in kot antineoplastično sredstvo pri zdravljenju dojk., endometrij, in rak prostate. Pri dajanju v relativno visokih odmerkih, pri večini posameznikov lahko znatno poveča apetit, tudi tisti z napredovalim rakom, in se pogosto uporablja za povečanje apetita in spodbujanje povečanja telesne mase pri bolnikih z rakom ali kaheksijo, povezano s HIV/aidsom. It is also used as a contraceptive in combination with an estrogen at relatively low doses.In addition to its use in humans, megestrol acetat se obširno uporablja v veterinarski medicini pri zdravljenju zdravstvenih stanj pri mačkah in psih.
