Serilesine
Sinónimos: Hexapeptide-10,Silitide
Fórmula: C28H53N7O8
Molecular:615.77
Secuencia: Ser-H- Ile-Lys-Val-Ala-Val-OH
Pureza (HPLC): 95.0% mín..
Apariencia :polvo blanco
Composición de aminoácidos: ±10% del teórico
Contenido de péptidos (NORTE%): ≥80,0%
Contenido de agua: ≤10,0%
Contenido de acetato: ≤15,0%
EM (ESI): Coherente
Mass Balance: 95.0~105,0%
Almacenamiento: -20ºC; Store in a cool dry place
Uso: La piel se reestructura, reabastecido (+19% de la densidad de la piel después 2 meses), firmer and more elastic, recovering its fullness.
Hexapeptide-10 is a synthetic peptide containing Alanine, Isoleucine, Lysine, Serine and Valine residues. It increases the synthesis of laminin V and α6-integrin to promote cell binding, with extraordinary visible skin restructuring and firming abilities.
Hexapeptide-10 promotes the rebuilding of collagens and helps reduce fine lines and pore size. It is a firming active that strengthens the dermo-epidermal junction.
The Hexapeptide-10 corresponds to residues 2099-2104 of the laminin α1 chain. Hexapeptide-10 has been shown to modulate tumor invasion, metastasis and angiogenesis. It also induced the synthesis of prostaglandin E2, interstitial collagenase, and gelatinase B in monocyte cell cultures. Laminin fragments containing the SIKVAV sequence may contribute to the inflammatory response at sites of wound healing. They may also play a role in the excessive induction of metalloproteinases in chronic inflammatory lesions.
Hexapeptide-10 is from an adhesion sequence of laminin, which restores the cutaneous structure.Hexapeptide-10 is a firming active that promotes a double-cellular activity on both keratinocytes and fibroblast. It increases the synthesis of laminin-5, alpha6-integrin and hemidesmosomes, thus strengthening the dermal-epidermal junction. With Hexapeptide-10,the skin is restructured, reabastecido, firmer and more elastic, recovering its fullness.
