Thymosin β4 ubiquitous est, 43-amino acidic polypeptide cum hypothetica pondere 4.9 kDa.It valde conservatur per species, et invenitur in omnibus fibris et generibus cellularum exceptis cellulis sanguineis rubris. Thymosin β4 est dapibus multifunctionalis qui cellam migrationem promovet, caulis cellula cooptatione et differentia, proteste productio, et expressio diversorum generum regulatorii, such as laminin-332, fibronectin, zyxin, VEGF, matrix metalloproteases, hepatocyte growth factor, and antioxidative enzymes (Table 1). It inhibits inflammation, microbial growth, scar formation (by reducing the level of myofibroblasts), and apoptosis, and protects cells from cytotoxic damage, including glutamate neuronal toxicity.Thymosin β4 binds to G-actin, blocks actin polymerization, and is coreleased with factor XIIIa by platelets, suggesting its importance in wound healing.
