Protirelin est l'analogue synthétique disponible en pharmacie de l'hormone peptidique endogène de libération de la thyrotropine. (TRH). C'est une hormone tropique tri-peptide, libéré par l'hypothalamus, qui stimule la libération de l'hormone stimulant la thyroïde (TSH) et prolactine de l'hypophyse antérieure.
Bien qu'il ne soit actuellement disponible dans aucun produit approuvé par la FDA, la protireline est un composant du test TRH où elle est utilisée pour tester la réponse de l'hypophyse antérieure dans des conditions telles que l'hypothyroïdie secondaire et l'acromégalie..
TRH is intended for intravenous administration with the patient in the supine position. The drug is administered as a bolus over a period of 15 à 30 seconds, with the patient remaining supine until all scheduled post injection blood samples have been taken. Blood pressure should be measured before TRH is administered and at frequent intervals during the first 15 minutes thereafter. Have the patient urinate before injecting TRH.
Previous work from our laboratory prompted us to study the effects of short-term, acute administration of TRH or its chronic oral administration, on organs, tissues and aging-related metabolic and hormonal markers, in order to acquire more knowledge on effects, dosage and timing of administration according to its circadian cyclicity. En outre, we wanted to verify its anti-aging effects on two most fundamental functions, namely gonadal- reproductive and kidney-urinary. The results demonstrate that both a short-term, acute or a chronic, long-term oral administration of TRH to old, aging mice, results into positive changes and rapid correction to more juvenile levels of most typical aging-related hormonal and metabolic alterations.
