Протирелин е фармацевтично достъпен синтетичен аналог на ендогенния пептид тиротропин-освобождаващ хормон (TRH). Това е трипептиден тропен хормон, освободен от хипоталамуса, който стимулира отделянето на тиреоиден стимулиращ хормон (TSH) и пролактин от предния дял на хипофизата.
Въпреки че в момента не се предлага в нито един продукт, одобрен от FDA, protirelin е компонент на TRH теста, където се използва за тестване на отговора на предната хипофизна жлеза при състояния като вторичен хипотиреоидизъм и акромегалия.
TRH is intended for intravenous administration with the patient in the supine position. The drug is administered as a bolus over a period of 15 към 30 seconds, with the patient remaining supine until all scheduled post injection blood samples have been taken. Blood pressure should be measured before TRH is administered and at frequent intervals during the first 15 minutes thereafter. Have the patient urinate before injecting TRH.
Previous work from our laboratory prompted us to study the effects of short-term, acute administration of TRH or its chronic oral administration, on organs, tissues and aging-related metabolic and hormonal markers, in order to acquire more knowledge on effects, dosage and timing of administration according to its circadian cyclicity. Освен това, we wanted to verify its anti-aging effects on two most fundamental functions, namely gonadal- reproductive and kidney-urinary. The results demonstrate that both a short-term, acute or a chronic, long-term oral administration of TRH to old, aging mice, results into positive changes and rapid correction to more juvenile levels of most typical aging-related hormonal and metabolic alterations.
