Dehidroepiandrosteroon/dehidroepiandrostenedion (DHEA, meer korrek didehydroepiandrosterone), ook bekend as androstenolone sowel as 3β-hidroksiandrost-5-en-17-one of 5-androsten-3β-ol-17-one, is 'n belangrike endogene steroïedhormoon. In sy farmaseutiese geneesmiddelvorm word dit prasteroon genoem (INN). Dit is die volopste sirkulerende steroïedhormoon by mense, by wie dit in die byniere geproduseer word, die gonades, en die brein, where it functions predominantly as a metabolic intermediate in the biosynthesis of the androgen and estrogen sex steroids. Egter, DHEA also has a variety of potential biological effects in its own right, binding to an array of nuclear and cell surface receptors, and acting as a neurosteroid.
In middle-aged men, no statistically significant effect of DHEA supplementation on lean body mass, strength, or testosterone levels was found in a randomized placebo-controlled trial.
A small study suggested DHEA supplementation was associated with increases in free (but not total) testosterone levels
In women with adrenal insufficiency and the healthy elderly there is insufficient evidence to support the use of DHEA.
