Prostaglandin E1 (PGE1), also known as alprostadil, is a naturally occurring prostaglandin which is used as a medication. In babies with congenital heart defects, it is used by slow injection into a vein to open the ductus arteriosus until surgery can be carried out. By injection into the penis or placement in the urethra, it is used to treat erectile dysfunction. Common side effects when given to babies include decreased breathing, 熱, and low blood pressure. When used for erectile dysfunction side effects may include penile pain, bleeding at the site of injection, and prolonged erection (priapism). Prostaglandin E1 is in the vasodilator family of medications. It works by opening blood vessels by relaxing smooth muscle. Prostaglandin E1 was isolated in 1957 米国では医療用途として承認されています。 1981. 世界保健機関の必須医薬品リストに載っています, 医療システムに必要な最も安全で最も効果的な医薬品.
1 .抗血小板凝集薬は、血小板放出トロンボキサン A2 を阻害することで血小板凝集を阻害します。 (TXA2), 血液粘度を低下させながら赤血球の変形性を改善し、それによって血液レオロジーを変化させます。.
2 .血管の拡張, 組織の酸素供給を改善する PGE1 は血管交感神経終末を阻害し、ノルエピネフリンを放出します, 血管平滑筋の拡張.
3. 炎症の抑制
