Prostaglandien E1 (PGE1), ook bekend as alprostadil, is 'n natuurlik voorkomende prostaglandien wat as 'n medikasie gebruik word. By babas met aangebore hartafwykings, dit word gebruik deur stadige inspuiting in 'n aar om die ductus arteriosus oop te maak totdat chirurgie uitgevoer kan word. Deur inspuiting in die penis of plasing in die uretra, dit word gebruik om erektiele disfunksie te behandel. Algemene newe-effekte wanneer dit aan babas gegee word, sluit in verminderde asemhaling, koors, en lae bloeddruk. When used for erectile dysfunction side effects may include penile pain, bleeding at the site of injection, and prolonged erection (priapism). Prostaglandin E1 is in the vasodilator family of medications. It works by opening blood vessels by relaxing smooth muscle. Prostaglandin E1 was isolated in 1957 and approved for medical use in the United States in 1981. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.
1 .Antiplatelet aggregation can inhibit platelet aggregation by inhibiting platelet release thromboxane A2 (TXA2), while reducing blood viscosity to improve red blood cell deformability and thereby alter hemorheology.
2 .Expansion of blood vessels, verbeter weefsel suurstofvoorsiening PGE1 kan die vaskulêre simpatiese senuwee-eindpunte inhibeer vrystel van norepinefrien, vaskulêre gladdespier uitbreiding.
3. Inhibisie van inflammasie
