Prostaglandin E1 (PGE1), also known as alprostadil, is a naturally occurring prostaglandin which is used as a medication. In babies with congenital heart defects, it is used by slow injection into a vein to open the ductus arteriosus until surgery can be carried out. By injection into the penis or placement in the urethra, it is used to treat erectile dysfunction. Common side effects when given to babies include decreased breathing, fever, and low blood pressure. When used for erectile dysfunction side effects may include penile pain, bleeding at the site of injection, and prolonged erection (priapism). Prostaglandin E1 is in the vasodilator family of medications. It works by opening blood vessels by relaxing smooth muscle. Prostaglandin E1 was isolated in 1957 and approved for medical use in the United States in 1981. Het staat op de lijst van essentiële geneesmiddelen van de Wereldgezondheidsorganisatie, the safest and most effective medicines needed in a health system.
1 .Antiplatelet aggregation can inhibit platelet aggregation by inhibiting platelet release thromboxane A2 (TXA2), while reducing blood viscosity to improve red blood cell deformability and thereby alter hemorheology.
2 .Expansion of blood vessels, improve tissue oxygen supply PGE1 can inhibit the vascular sympathetic nerve endings release norepinephrine, vascular smooth muscle expansion.
3. Inhibition of inflammation
