Angiotensin II is an octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. It is part of the renin angiotensin system, wat 'n groot teiken is vir middels wat bloeddruk verlaag. Angiotensien stimuleer ook die vrystelling van aldosteroon, another hormone, from the adrenal cortex. Aldosteroon bevorder natriumretensie in die distale nefron, in die nier, wat ook bloeddruk opjaag.
Angiotensien is 'n oligopeptied en is 'n hormoon en 'n kragtige dipsogeen. Dit is afgelei van die voorlopermolekule angiotensiegeen, 'n serumglobulien wat in die lewer geproduseer word. Dit speel 'n belangrike rol in die renien-angiotensienstelsel.
