Enfuvirtide Acetate (T-20)
نام مستعار:Fuzeon
دنباله:CH3CO-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
Cas No. : 159519-65-0
فرمول مولکولی : C204H301N51O64
وزن مولکولی : 4492
خلوص (HPLC) : 98.0%دقیقه.
ظاهر : White to off-white amorphous solid
ناخالصی منفرد (HPLC) : 0.5%حداکثر
ترکیب اسید آمینه : ± 10 درصد نظری
محتوای پپتید (N%) : ≥80.0٪
محتوای آب (کارل فیشر) : ≤8.0٪
TrifluoroAcetate Content(HPIC) : ≤12.0٪
اماس (ESI) : سازگار
توازن جرم : 95.0~ 105.0٪
درجه : درجه دارویی
ذخیره سازی: بسته شد, زیر 2 ~ 8℃ preservation
استفاده : Treatment option for patients suffering from HIV/AIDS.
Enfuvirtide is an antiretroviral drug used in combination therapy for the treatment of HIV-1/AIDS. It binds to the first heptad-repeat (HR1) in the gp41 subunit of the viral envelope glycoprotein and prevents the conformational changes required for the fusion of viral and cellular membranes. It works by disrupting the HIV-1 molecular machinery at the final stage of fusion with the target cell, preventing uninfected cells from becoming infected.
Enfuvirtide (INN) is an HIV fusion inhibitor, the first of a novel class of antiretroviral drugs used in combination therapy for the treatment of HIV-1 infection. It is marketed under the trade name Fuzeon (Roche).
