Produktnavn: Larazotide
CAS-nr:258818-34-7
Sekvens:Glycylglycyl-L-valyl-L-leucyl-L-valyl-L-glutaminyl-L-prolylglycine
Molekylær formel: C32H55N9O10
Molekylvekt: 725.83 g/mol
Spesifikasjon: 1mg/Vials
Renhet : 98% HPLC
Utseende: Hvitt lyofilisert pulver
Typical use: Celiac Therapy
Standard Packing: 10vials/kits
Larazotide (VERTSHUS; also known as AT-1001; formulated as the salt with acetic acid, larazotide acetate) is a synthetic eight amino acid peptide that functions as a tight junction regulator and reverses leaky junctions to their normally closed state. It is being studied in people with celiac disease.
Larazotide is an octapeptide whose structure is derived from a protein (zonula occludens toxin) secreted by Vibrio cholerae. It has the amino acid sequence GGVLVQPG, IUPAC condensed descriptor of H-Gly-Gly-Val-Leu-Val-Gln-Pro-Gly-OH, and the systematic name glycylglycyl-L-valyl-L-leucyl-L-valyl-L-glutaminyl-L-prolyl-glycine.
