Medrogestone, sold under the brand name Colprone among others, is a progestin medication which has been used in menopausal hormone therapy and in the treatment of gynecological disorders.It is available both alone and in combination with an estrogen.It is taken by mouth.
Medrogestone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone.It has weak antiandrogenic, glucocorticoid, and antimineralocorticoid activity and no other important hormonal activity.Due to its progestogenic activity, medrogestone has antigonadotropic effects
In the past, medrogestone was used in the treatment of endometrial cancer and in some regimens for breast cancer, و, in men, for benign prostatic hyperplasia. It still finds use in the treatment of amenorrhea and as the progestin component in certain forms of menopausal hormone therapy.
