Pramlintide CAS:151126-32-8

پراملینتاید (نام تجاری Symlin) یک داروی آنالوگ آمیلین تزریقی برای دیابت است (هر دو نوع 1 و 2), توسعه یافته توسط Amylin Pharmaceuticals (اکنون یک شرکت تابعه کاملاً متعلق به AstraZeneca است).پراملینتید به عنوان نمک استات فروخته می شود.

پراملینتید آنالوگ آمیلین است, a small peptide hormone that is released into the bloodstream by the β cells of the pancreas along with insulin after a meal.Like insulin, amylin is completely absent in individuals with Type I diabetes.

In synergy with endogenous amylin, pramlintide aids in the regulation of blood glucose by slowing gastric emptying, promoting satiety via hypothalamic receptors (different receptors than for GLP-1), and inhibiting inappropriate secretion of glucagon, a catabolic hormone that opposes the effects of insulin and amylin. Pramlintide also has effects in raising the acute first-phase insulin response threshold following a meal.

Both a reduction in glycated hemoglobin and weight loss have been shown in insulin-treated patients with type 2 diabetes taking pramlintide as an adjunctive therapy.