Secretin
Séquence:H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2
Alias : Secretin, Pig secretin, Porcine secretin, Secrepan, Secretin-Ferring, Sekretolin,Human Secretin
Cas No.: 17034-35-4
EINECS : 241-105-3
Formule moléculaire: C130H220N44O41
Poids moléculaire: 3055.47
Pureté (HPLC): 98.0%min.
Apparence: Poudre blanche
Impureté unique (HPLC): 1.0%maximum
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): >80.0%
Teneur en eau(Karl Fischer): <6.0%
Contenu en acétate (HPIC): <15.0%
MS(ESI): Consistent
Mass Balance: 95.0~105,0%
Grade : Qualité pharmaceutique
Stockage: Closed, below 2 ~ 8℃ preservation
Usage : L'acétate de sécrétine est une hormone responsable du contrôle de l'environnement du duodénum en régulant les sécrétions pancréatiques et gastriques tout en régulant l'homéostasie de l'eau dans tout le corps d'un animal.. Spécifiquement, il aide à réguler le pH du duodénum en inhibant la sécrétion d'acide gastrique par les cellules pariétales de l'estomac et en augmentant la production de bicarbonate dans les cellules centroacinaires du pancréas.
Secretin is a hormone that regulates water homeostasis throughout the body and influences the environment of the duodenum by regulating secretions in the stomach, pancreas, and liver. It is a peptide hormone produced in the S cells of the duodenum, which are located in the intestinal glands.In humans, the secretin peptide is encoded by the SCT gene.
Secretin helps regulate the pH of the duodenum by inhibiting the secretion of gastric acid from the parietal cells of the stomach and stimulating the production of bicarbonate from the ductal cells of the pancreas.It also stimulates the secretion of bicarbonate and water by cholangiocytes in the bile duct, protecting it from bile acids by controlling the pH and promoting the flow in the duct.Meanwhile, in concert with secretin's actions, the other main hormone simultaneously issued by the duodenum, cholecystokinin (CCK), is stimulating the gallbladder to contract, delivering its stored bile.
