Nom du produit :Calcitonin salmon
Trade Name:Saleatonin
N° CAS:47931-85-1
Formule moléculaire: C145H240N44O48S2
Poids moléculaire:3431.85g/mole
Pureté : 98% HPLC
Apparence: Poudre lyophilisée
Utilisation typique:Treatment of Osteoporosis
Calcitonin (salmon) is an hypocalcemic hormone produced by the parafollicular C cells of the thyroid or by the ultimobranchial bodies of nonmammalian vertebrates. Calcitonin decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes. Calcitonin contains a single disulfide bond, which causes the amino terminus to assume the shape of a ring. Alternative splicing of the calcitonin pre-mRNA can yield a mRNA encoding calcitonin gene-related peptide; that peptide appears to function in the nervous and vascular systems. The calcitonin receptor has been cloned and shown to be a member of the seven-transmembrane, G protein-coupled receptor family.
-Treatment of postmenopausal women with osteoporosis at high risk for fracture
-Increase of bone mass in men with primary or hypogonadal osteoporosis at high risk for fracture
-Treatment of men and women with osteoporosis associated with sustained systemic glucocorticoid therapy at high risk for fracture
| Article |
Standard |
Résultats des tests |
| Identification |
A.H-RMN:Respecter la structure |
Conforme |
|
B.LC-MS:Respecter la structure |
Conforme |
|
C. Le spectre IR de l'échantillon doit être identique à celui de l'étalon de référence; |
Conforme |
|
D.HPLC-ESI-MS
Le temps de rétention du pic majeur dans le chromatogramme de la préparation Test correspond à celui du chromatogramme de la préparation Standard, tel qu'obtenu dans le test. |
Conforme |
| Crystallinity |
meets the requirements. |
Conforme |
| Perte au séchage |
≤2,0% |
0.19% |
| Métaux lourds |
≤10 ppm |
<10ppm |
| Eau |
≤1,0% |
0.1% |
| Cendres sulfatées |
≤0,5%, déterminé sur 1.0 g. |
0.009% |
| Substances apparentées |
Impuretés non précisées: for each impurity |
<0.10% |
|
Impureté totale |
0.18% |
| Pureté |
≥99,0 % |
99.7% |
| Essai |
99.0%~101,0% (anhydrous substance). |
99.8% |
| Analyse microbiologique |
|
|
| Nombre total de plaques |
≤1000 ufc/g |
Conforme |
| Yeast and Moulds |
≤100 ufc/g |
Conforme |
| E. Coli. |
Absent |
Négatif |
| Salmonelle |
Absent |
Négatif |
| S.aureus |
Absent |
Négatif |
| Stockage |
Preserve in well-closed, light-resistant and airtight containers. |
Conforme |
