Allopregnanolone is a naturally occurring neurosteroid which is made in the body from the hormone progesterone.As a medication, allopregnanolone is referred to as brexanolone, sold under the brand name Zulresso,and used to treat postpartum depression. It is used by injection into a vein over a 60-hour period under medical supervision.
Side effects of brexanolone may include sedation, sleepiness, dry mouth, hot flashes, and loss of consciousness.It is a neurosteroid and acts as a positive allosteric modulator of the GABAA receptor, die belangrikste biologiese teiken van die inhiberende neurotransmitter γ-aminobottersuur (GABA).
Brexanolone is in 2019 vir mediese gebruik in die Verenigde State goedgekeur. Voedsel- en dwelmadministrasie (FDA) beskou dit as 'n eersteklas medikasie.Die lang toedieningstyd, asook die koste vir 'n eenmalige behandeling, het kommer uitgespreek oor toeganklikheid vir baie vroue.
