Exenatide Acetate CAS:141732-76-5

Exendin-4 (exenatide), a 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increase in acinar CAMP without stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide has found use as a medication of diabetes II.

Exenatide Acetate is a polypeptide composed of 39 amino acids.It is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 value of 3.22 NM.

Application of exenatide acetate causes an increase in acinar CAMP without stimulating amylase release. As an incretin mimetic, exenatide acetate acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide acetate augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide acetate has found use as a medication of diabetes II.

Exenatide is a synthetic version of Exendin-4, an insulin secretagogue with glucoregulatory effects. It displays biological properties similar to human Glucagon-Like Peptide-1 (GLP-1), a regulator of glucose metabolism and insulin secretion. Exenatide enhances glucose-dependent insulin secretion by the pancreatic beta-cell, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying.

外観: 白い粉
単一の不純物 (HPLC): 1.0%最大
アミノ酸組成: ± 10% of theoretical
ペプチド含有量 (N%): ≥ 80.0%
水分含有量(カール・フィッシャー): ≤ 10.0%
アセテート含有量(HPIC): ≤ 12.0%
MS(ESI): 一貫性のある
マスバランス: 95.0～105.0%