Synonyme: (DES-GLY10,PRO-NHET9)-LHRH;[DES-GLY10] LH-RH, ETHYL AMIDE
CAS-NR.: 38234-21-8
EINECS-Nr.:636-807-5
Molekulare Formel: C55H76N16O12
Molekulargewicht: 1153.29 g/mol
Reinheit: 99%min
Aussehen: weißes Pulver
Fertirelin is a synthetic luteinizing hormone-releasing hormone (LH-RH) analogue, and it is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.
Fertirelin was administered at the beginning of the protocol followed 7 days later by 500 μ G cloprosterol. Two days later, a second dose of fertirelin was given and AI performed 16-19 h later regardless of the incidence of behavioral oestrus. The conception rate did not differ between the 50 μ G fertirelin group (61.1%; N = 72) and the 100 μ G group.
Mainly has a strong angiotensin II vasoconstriction and increase in blood pressure. The mechanism is: 1. So that the body arteriole smooth muscle contraction, increased peripheral resistance; 2. So increase the release of adrenal aldosterone, causing sodium retention, increased blood volume; 3. Directly contribute to renal tubular sodium and water reabsorption; 4. So the brain central nervous sympathetic vasoconstrictor activity, causing increased peripheral vascular resistance; 5. Stimulate the adrenal medulla to release epinephrine and norepinephrine.
| Reinheit (HPLC) |
99.0% |
| Aussehen |
Weißes Pulver |
| Einzelne Verunreinigung(HPLC) |
1.0% |
| Aminosäurezusammensetzung |
10% of theoretical |
| Peptidgehalt(N%) |
80%(von %N) |
| Wassergehalt(Karl Fischer) |
6.0% |
| Acetatgehalt(HPIC) |
15.0% |
| MS(ESI) |
|
| Mass Balance |
95.0～105.0% |
