Follistatin 315

Follistatin, also called activin-binding protein, is found in nearly all tissues of vertebrate animals. Its primary function is to neutralize members of the TGF-β family, which play fundamental roles in everything from growth and development to energy homeostasis and immune system regulation. In particular, follistatin interacts with activin, which plays an important part in cell proliferation and cell death as well as in the immune response as it applies to wound repair.

Follistatin 344 og 315 are engineered analogues of naturally occurring follistatin. Both are created by alternative splicing of the follistatin mRNA transcript. Scientific research in non-human primates as well as in mice have indicated that both molecules are capable of improving muscle growth by antagonizing myostatin (a member of the TGF-β family).

Follistatin er fascinerende protein som kan øke muskelmassen utover det naturlige potensialet ved å undertrykke myostatin. Forskere identifiserte først follistatin mens de undersøkte svin (re: gris) follikulær væske i eggstokkene.

Follistatin finnes naturlig i skjelettmuskulaturen til nesten alle pattedyr med avanserte eller utviklede egenskaper, slik som mennesker, gnagere, og kyr. Follistatin er høyt i den ikke-essensielle aminosyren cystin, men i motsetning til de fleste proteiner som diskuteres i treningsverdenen, follistatin har karbohydrater knyttet til seg.