Follistatien 315

Follistatien, also called activin-binding protein, is found in nearly all tissues of vertebrate animals. Its primary function is to neutralize members of the TGF-β family, which play fundamental roles in everything from growth and development to energy homeostasis and immune system regulation. In particular, follistatin interacts with activin, which plays an important part in cell proliferation and cell death as well as in the immune response as it applies to wound repair.

Follistatien 344 en 315 are engineered analogues of naturally occurring follistatin. Both are created by alternative splicing of the follistatin mRNA transcript. Scientific research in non-human primates as well as in mice have indicated that both molecules are capable of improving muscle growth by antagonizing myostatin (a member of the TGF-β family).

Follistatien is fassinerende proteïen wat spiermassa bo natuurlike potensiaal kan verhoog deur miostatien te onderdruk. Wetenskaplikes het follistatien eers geïdentifiseer terwyl hulle varke ondersoek het (her: vark) follikulêre vloeistof in die eierstokke.

Follistatien word natuurlik in die skeletspier van byna alle soogdiere met gevorderde of ontwikkelde eienskappe aangetref, soos mense, knaagdiere, en koeie. Follistatien is hoog in die nie-essensiële aminosuur sisteien, maar anders as die meeste proteïene wat in die fiksheidswêreld bespreek word, follistatien het koolhidrate daaraan gekoppel.