Fulvestrant همچنین Faslodex یا AstraZeneca نامیده می شود,یک درمان دارویی سرطان سینه متاستاتیک گیرنده مثبت هورمونی در زنان یائسه با پیشرفت بیماری به دنبال درمان ضد استروژن است.. با مسدود کردن فعالیت استروژن در بدن عمل می کند. Fulvestrant یک آنتاگونیست کامل گیرنده استروژن بدون اثرات آگونیستی است, که علاوه بر این, تخریب پروتئازومی گیرنده استروژن را تسریع می کند. این دارو فراهمی زیستی خوراکی ضعیفی دارد, and is administered monthly via intramuscular injection.Certain types of breast cancer use estrogen to grow and multiply in the body.do not use fulvestrant if you are allergic to any ingredient in fulvestrant ,and Contact your doctor or health care provider right away if any of these apply to you.
Many breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone. These breast cancers are called hormone sensitive or hormone receptor positive. Drugs that block the effects of these hormones can slow or stop the growth of the breast cancer cells. Fulvestrant stops oestrogen getting to the cancer cells by blocking oestrogen receptors and reducing the number of receptors the cancer cell has.
Fulvestrant Acetate (فاسلودکس, AstraZeneca) is a drug treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. It is an estrogen receptor antagonist with no agonist effects, which works by down-regulating the estrogen receptor.
Fulvestrant Acetate is a selective estrogen receptor down-regulator (SERD). Fulvestrant is indicated for the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. The dosing schedule for fulvestrant remains under investigation in an attempt to optimize its effectiveness.
