Humanin est endogenous peptidium mitochondriacum derivatum, quod effectus cytoprotectivos habet et accentus oxidative minuit. Experimenta utentes cellulis excultis demonstraverunt humaninum tam neuroprotectivos quam cytoprotectivos effectus et experimenta in rodentibus habere, quod effectus tutelae in morbis Alzheimeri exemplaribus habere., Morbi exemplaribus et plaga exemplaribus Huntington's. Humanin proponitur habere effectus myrias neuroprotectivos et cytoprotectivos. Ambo studia in cellis et rodentibus pariter invenerunt administrationem derivatorum humaninorum vel humaninorum superstes et/vel parametrorum physiologicorum in exemplorum morborum Alzheimerorum..
Humanin membrum est novae familiae peptidum quae brevibus tabulis apertis intra genoma mitochondriale enodantur.. Conservatur in animalibus et est neuroprotectivum et cytoprotectivum. Hic nuntiamus in C. elegans overexpression of humanin satis augere, daf dependens XVI / Foxo. Humanin transgenic mures multa phaenotypa quae aliudque cum phaenotypis vermibus et, similis exogenous humanin curatio, toxicus contra contumelias auxit praesidium. Tractat mediae aetatis mures bis weekly cum potenti humanin analogo HNG, humanin improves metabolic healthspan parameters and reduces inflammatory markers. In multiple species, humanin levels generally decline with age, but here we show that levels are surprisingly stable in the naked mole-rat, a model of negligible senescence. Ceterum, in children of centenarians, who are more likely to become centenarians themselves, circulating humanin levels are much greater than age-matched control subjects. Further linking humanin to healthspan, we observe that humanin levels are decreased in human diseases such as Alzheimer's disease and MELAS (Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like episodes). Together, these studies are the first to demonstrate that humanin is linked to improved healthspan and increased lifespan.
