Naam: Levobupivacaine Base
Synoniemen:1-Butyl-N-(2,6-dimethylfenyl)-piperidine-2-carboxamide;Chirocaine;Levobupivacaine;(2S)-1-Butyl-N-(2,6-dimethylfenyl)piperidine-2α-carboxamide;2′,6′-Pipecoloxylidide, 1-butyl-, L-(-)-;1-Butyl-N-(2,6-afm;;(2S)-1-Butyl-N-(2,6-dimethylfenyl)-2-piperidinecarboxaMide
CAS:27262-47-1
MF:C18H28N2O
Mw:288.43
Smeltpunt:136-137°C
Chemische eigenschappen:Witte vaste stof
Gebruik :Lokale verdoving gebruikt voor epidurale en intrathecale anesthesie.
Levobupivacaine is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by Abbott under the trade name Chirocaine. Levobupivacaine is indicated for local anaesthesia including infiltration, zenuwblokkade, ophthalmic, epidural and intrathecal anaesthesia in adults; and infiltration analgesia in children. Compared to bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action. It is approximately 13 percent less potent (by molarity) than racemic bupivacaine and has a longer motor block onset time.
Clinical Use
Compared to bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action. It is approximately 13 percent less potent (by molarity) than racemic bupivacaine and has a longer motor block onset time.
Indications
Levobupivacaine is indicated for local anaesthesia including infiltration, zenuwblokkade, ophthalmic, epidural and intrathecal anaesthesia in adults; and infiltration analgesia in children.
Contraindications
Levobupivacaine is contraindicated for IV regional anaesthesia (IVRA).
