Nestorone Acetate CAS:7759-35-5

Nestorone is a potent progesterone receptor agonist with no androgenic, estrogenic, or glucocorticoid-like activities. Nestorone has been used as a female contraceptive, and recent studies inidicate that it may be useful as a male contraceptive as well. It has also been shown to have neurogenic and neuroprotective activity.

Segesterone acetate (SGA), sold under the brand names Nestorone, Elcometrine, and Annovera, je progestínový liek, ktorý sa používa pri kontrole pôrodnosti a pri liečbe endometriózy v Spojených štátoch, Brazília, a ďalších juhoamerických krajinách. Je dostupný samostatne aj v kombinácii s estrogénom. Nie je účinný ústami a musí sa podávať inými cestami, najčastejšie ako vaginálny krúžok alebo implantát, ktorý je umiestnený do tuku.

Vedľajšie účinky SGA sú podobné ako pri iných progestínoch. SGA je progestín, alebo syntetický gestagén, a je teda agonistom progesterónového receptora, biologický cieľ gestagénov, ako je progesterón. Má určitú afinitu ku glukokortikoidovému receptoru a nemá žiadnu inú dôležitú hormonálnu aktivitu.

SGA was developed by the Population Council and was introduced for medical use by 2000.It is under development in the United States and Europe as a gel in combination with estradiol or testosterone for use as a method of birth control in women and in men, respectively.On August 10, 2018, a first-of-its-kind one-year contraceptive vaginal ring containing segesterone acetate in combination with ethinyl estradiol was approved in the United States.It is marketed under the brand name Annovera and is reusable for up to one year as a method of birth control in women. Annovera does not require refrigeration which is very useful for low resource areas