CAS: 53179-13-8
MF: C12H11NO
Mw: 185.22
Verschijning: A little yellow to white powder
Zuiverheid: 99.70%
Houdbaarheid: 3 jaar
Standaard: Enterprise standard
Gebruik: Pirfenidon heeft activiteit aangetoond bij meerdere fibrotische aandoeningen, inclusief die van de long, nier en lever.
n vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - bèta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - bèta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice.
Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.
Pirfenidon heeft activiteit aangetoond bij meerdere fibrotische aandoeningen, inclusief die van de long, kidney and liver.Biological Activity Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo . Potent scavenger of free radicals and inhibitor of lipid peroxidation.
