Ime: Plecanatide
št. CAS. :467426-54-6
Zaporedje: H-Asn-Asp-Glu-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH
Molekulska formula: C65H104N18O26S4
Molekulska teža : 1681.88
Čistost: >98.0%
Vir: sintetični
Plecanatide is a structural analog of human uroguanylin, and similarly to uroguanylin, plecanatide functions as a guanylate cyclase-C (GC-C) agonist. Both plecanatide and its active metabolite bind to GC-C and act locally on the luminal surface of the intestinal epithelium. Activation of GC-C results in an increase in both intracellular and extracellular concentrations of cyclic guanosine monophosphate (cGMP).
Plecanatide is used in adults to treat chronic idiopathic constipation (CIC; oteženo ali redko odvajanje blata, ki traja 3 mesecev ali več in ni posledica bolezni ali zdravil) and irritable bowel syndrome with constipation (IBS-C; a condition that causes stomach pain or cramps, napenjanje, and constipation.)
Plecanatide is in a class of medications called guanylate cyclase-C agonists. It works by increasing the movement of food and waste through the stomach and intestines.
