Nazwa: Plecanatide
Nr CAS. :467426-54-6
Sekwencja: H-Asn-Asp-Glu-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH
Formuła molekularna: C65H104N18O26S4
Masa cząsteczkowa : 1681.88
Czystość: >98.0%
Źródło: syntetyczny
Plecanatide is a structural analog of human uroguanylin, and similarly to uroguanylin, plecanatide functions as a guanylate cyclase-C (GC-C) agonist. Both plecanatide and its active metabolite bind to GC-C and act locally on the luminal surface of the intestinal epithelium. Activation of GC-C results in an increase in both intracellular and extracellular concentrations of cyclic guanosine monophosphate (cGMP).
Plecanatide is used in adults to treat chronic idiopathic constipation (CIC; trudne lub rzadkie oddawanie stolca, które trwa 3 miesięcy lub dłużej i nie jest spowodowane chorobą ani lekiem) and irritable bowel syndrome with constipation (IBS-C; a condition that causes stomach pain or cramps, wzdęcia, and constipation.)
Plecanatide is in a class of medications called guanylate cyclase-C agonists. It works by increasing the movement of food and waste through the stomach and intestines.
