Plecanatides CAS:467426-54-6

Plecanatide is a structural analog of human uroguanylin, and similarly to uroguanylin, plecanatide functions as a guanylate cyclase-C (GC-C) agonist. Both plecanatide and its active metabolite bind to GC-C and act locally on the luminal surface of the intestinal epithelium. Activation of GC-C results in an increase in both intracellular and extracellular concentrations of cyclic guanosine monophosphate (cGMP).

Plecanatide is used in adults to treat chronic idiopathic constipation (CIC; moeilike of ongereelde gang van stoelgang wat duur vir 3 maande of langer en word nie deur 'n siekte of 'n medikasie veroorsaak nie) and irritable bowel syndrome with constipation (IBS-C; a condition that causes stomach pain or cramps, opgeblasenheid, and constipation.)

Plecanatide is in a class of medications called guanylate cyclase-C agonists. It works by increasing the movement of food and waste through the stomach and intestines.