英語の同義語: 2- (プロピルアミノ) プロピオン-o-トルイジド; N- (2-メチルフェニル) -2- (プロピルアミノ) プロパアミド; Prilocaine base
CAS: 721-50-6
EINECS番号: 211-957-0
式: C13H20N2O
分子量: 220.31
水溶性: 水とエタノールに溶ける, クロロホルムにわずかに溶ける
アッセイ:99%
外観: 白色の結晶性粉末
Prilocaine is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Lö Fgren.
注射可能な形で (trade name Citanest), 歯科でよく使われます. 皮膚麻酔の準備としてリドカインと併用されることもよくあります。 (リドカイン/プリロカインまたはEMLA), 感覚異常などの症状の治療用. 心毒性が低いので, it is commonly used for intravenous regional anaesthesia (IVRA).Prilocaine belongs to amide local anesthetic drug with its anesthesia intensity and speed being similar as lidocaine but with a longer duration period and weaker effect on vasodilation. It has a lower toxicity than lidocaine. It is clinically for local anesthesia, especially suitable for treating patients who are not allowed to use adrenaline.
麻酔, 地元- プロパラカインとテトラカインは、眼圧測定などの眼科処置において短時間の局所麻酔を行うことが示されています。, 異物や縫合糸の除去, 診断および隅角鏡検査における結膜および角膜の擦過.
prilocaine topical cream is used on the skin or in the genital area to cause numbness or loss of feeling before certain medical procedures. It is used to prevent pain caused by an injection, the drawing of blood from a vein, or minor surgeries such as removing warts. This medicine contains a mixture of two topical local anesthetics. 皮膚の神経終末を鈍化させます. Relieving pain of normal intact skin and numbing skin to pain from injections and other medical procedures. prilocaine cream is a local anesthetic. It works by blocking nerves from transmitting painful impulses to the brain Prilocaine Hydrochloride Injection, 米国薬局, 4% is a sterile, non pyrogenic isotonic solution that contains a local anesthetic agent and is administered parenterally by injection. See indications and usage for specific uses.
Prilocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action.Excessive blood levels may cause changes in cardiac output, total peripheral resistance, and mean arterial pressure. These changes may be attributable to a direct depressant effect of the local anesthetic agent on various components of the cardiovascular system. Prilocaine crosses the blood-brain and placental barriers, presumably by passive diffusion. Factors such as acidosis and the use of CNS stimulants and depressants affect the CNS levels of prilocaine required to produce overt systemic effects. In the rhesus monkey, arterial blood levels of 20 mg/mL have been shown to be the threshold for convulsive activity.
