Mepivacaine Hydrochloride, a tertiary amine used as a local anesthetic, is 1-methyl-2', 6' - pipecoloxylidide monohydrochloride.
A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route.
メピビカインはアミドタイプの局所麻酔薬です. メピビカインは、適度に急速な発現と中程度の持続時間として知られており、カルボカインおよびポロカインという独自の名前で知られています。. メピビカインは局所浸潤および局所麻酔に使用されます. 局所麻酔薬の全身吸収は心血管系および中枢神経系に影響を及ぼします。. 通常の治療用量で達成される血中濃度で, 心臓伝導の変化, 興奮性, 耐火性, 収縮性, 末梢血管抵抗は最小限です.
Mupivacaine hydrochloride to stabilize the neuronal membrane, to prevent the occurrence and spread of nerve impulses, and thus local anesthesia.
The rapid metabolism of mepivacaine hydrochloride, only a small part of the anesthetic (5% に 10%) excretion in the urine unchanged. Methapine is not detoxified by circulating plasma esterase because of its amide structure. The liver is the main site of metabolism, more than 50% of the dose as a metabolite is excreted into the bile. Most metabolized mepivacaine may be absorbed in the intestine and then excreted into the urine because only a small fraction is found in the feces.
The main way to excrete is through the kidneys. Most anesthetics and their metabolites are eliminated within 30 時間. It has been shown that hydroxylation and N-demethylation as detoxification play an important role in the metabolism of anesthetics. Three metabolites of mepivacaine have been identified from adults: two phenols are almost completely excreted as glucuronide conjugates, and N-demethylated compounds (2 & apos;, 6 & apos; Oxygen).
