Име: Raloxifene
CAS номер: 84449-90-1
Формула: C28H27NO4S
Молекулно тегло: 473.58
Синоними: Кеоксифен;LY 139481;[2-(4-Хидроксифенил)-6-хидроксибензо[b]тиен-3-ил][4-(2-(1-пиперидинил)етокси)фенил]метанон;
Плътност: 1.289 g/cm3
Точка на топене: 250-253 °C
Точка на кипене: 728.2 °C при 760 mmHg
Пламна точка: 394.2 °C
Разтворимост: DMSO: 28 mg/mL, soluble
Външен вид: light-yellow solid
Използване : Смесен агонист/антагонист на нестероиден естрогенен рецептор
Raloxifene, a member of the class of selective estrogen receptor modulators (SERM), reproduces the beneficial effects of estrogens on the skeletal systems, without the negative effects estrogens on breast and endometrium.
This is a review article summarizing its mechanism, effects on bone and its applicability in traumatology clinical practice. In postmenopausal osteoporosis, this drug has been proven to decrease accelerated bone turnover, increase bone mineral density (BMD), and to structurally recover bone, decreasing the risk of vertebral fractures and the risk of non-vertebral fractures in patients with previous, severe vertebral fractures.
Raloxifene may increase your risk of a blood clot in your leg, your lung, or your eye.You should not take raloxifene if you have ever had this type of blood clot.
Raloxifene can also increase your risk of a stroke, which can be fatal. This risk is highest if you have certain risk factors (such as smoking, having heart problems or high blood pressure, or if you have ever had a heart attack or a stroke).
Although this medicine is for use only in postmenopausal women, you should not take raloxifene if you are pregnant or breastfeeding.
| АРТИКУЛИ |
СПЕЦИФИКАЦИЯ |
РЕЗУЛТАТ |
| Външен вид |
Бяло &off-white powder |
Съответства |
| Степен |
Anti Estrogen Steroids |
Съответства |
| Разтворимост |
Soluble in 10% sodium hydroxide solution. Slightly Soluble in methanol. Insoluble in water |
Съответства |
| Identifications |
Инфрачервена абсорбция |
Съответства |
| Загуба при сушене |
≤0,5% |
0.4% |
| Остатък при запалване |
≤0,1% |
0.06% |
| Тежки метали |
≤10ppm |
Съответства |
| Raloxifene Impurity1 |
≤0.20 % |
0.10% |
| Any unspecified individual impurity 2 |
≤0,10% |
Max. 0.08% |
| Общи примеси |
≤0,50% |
0.40% |
| Raloxifene |
≥98,0% |
99.0% |
