Naam: Raloxifene
CAS No.: 84449-90-1
Formule: C28H27NO4S
Molekulêre gewig: 473.58
Sinonieme: Keoksifene;LY 139481;[2-(4-Hidroksifeniel)-6-hidroksibenso[b]tien-3-yl][4-(2-(1-piperidiniel)etoksie)feniel]metanoon;
Digtheid: 1.289 g/cm3
Smeltpunt: 250-253 °C
Kookpunt: 728.2 °C by 760 mmHg
Flitspunt: 394.2 °C
Oplosbaarheid: DMSO: 28 mg/ml, oplosbaar
Voorkoms: liggeel vaste stof
Gebruik : 'n Niesteroïdale estrogeenreseptor gemengde agonis/antagonis
Raloxifene, 'n lid van die klas selektiewe estrogeenreseptormoduleerders (SERM), reproduseer die voordelige uitwerking van estrogeen op die skeletstelsels, sonder die negatiewe uitwerking van estrogeen op bors en endometrium.
Hierdie is 'n oorsigartikel wat die meganisme daarvan opsom, effekte op been en die toepaslikheid daarvan in traumatologie kliniese praktyk. In postmenopousale osteoporose, Daar is bewys dat hierdie middel versnelde beenomset verminder, verhoog beenmineraaldigtheid (BMD), en om struktureel been te herstel, decreasing the risk of vertebral fractures and the risk of non-vertebral fractures in patients with previous, severe vertebral fractures.
Raloxifene may increase your risk of a blood clot in your leg, your lung, or your eye.You should not take raloxifene if you have ever had this type of blood clot.
Raloxifene can also increase your risk of a stroke, which can be fatal. This risk is highest if you have certain risk factors (such as smoking, having heart problems or high blood pressure, or if you have ever had a heart attack or a stroke).
Although this medicine is for use only in postmenopausal women, you should not take raloxifene if you are pregnant or breastfeeding.
| ITEMS |
SPESIFIKASIE |
RESULTAAT |
| Voorkoms |
Wit &spierwit poeier |
Konformeer |
| Graad |
Anti Estrogen Steroids |
Konformeer |
| Oplosbaarheid |
Oplosbaar in 10% natriumhidroksied oplossing. Slightly Soluble in methanol. Onoplosbaar in water |
Konformeer |
| Identifications |
Infrarooi Absorpsie |
Konformeer |
| Verlies by droog |
≤0,5% |
0.4% |
| Residu by ontsteking |
≤0,1% |
0.06% |
| Swaar metale |
≤10 dpm |
Konformeer |
| Raloxifene Impurity1 |
≤0.20 % |
0.10% |
| Enige ongespesifiseerde individuele onreinheid 2 |
≤0,10% |
Maks. 0.08% |
| Totale onsuiwerhede |
≤0,50% |
0.40% |
| Raloxifene |
≥98,0% |
99.0% |
