Secretine-acetaat is een hormoon dat verantwoordelijk is voor het controleren van de omgeving van de twaalfvingerige darm door de secreties van de pancreas en de maag te reguleren en tegelijkertijd de waterhomeostase in het hele lichaam van een dier te reguleren.. Specifiek, het helpt de pH van de twaalfvingerige darm te reguleren door de afscheiding van maagzuur uit de pariëtale cellen van de maag te remmen en de stimulatie van de bicarbonaatproductie in de centroacinarcellen uit de pancreas te verhogen.
The first species was found in animal hormone. As a basic polypeptide. Composed of 27 aminozuurresten, containing 11 kinds of amino acids. Bayless and Starling (Bayliss and Starling) is equal to the discovery in 1902. Generated secretin cells as the "S" cells, mainly in the duodenal mucosa, a small amount of the distribution in the jejunum, ileum and gastric antrum.
Secretine-acetaat, also called secretin, has recently been in the brain and purified, therefore also joined the ranks of brain gut peptide. Role in stimulating the pancreas to secrete large amounts of bicarbonate rich pancreatic juice, to produce maximal stimulation of secretin dose on human, dog, pig, as an intravenous injection or intravenous infusion per kg per hour 1 clinical units, the equivalent of 200 naar 250 ng, strengthen weak effect on pancreatic enzyme secretion, but as with Pro pancreozymin given together, increased pancreozymin secretion, has inhibitory effect on human, dog, rat gastric acid secretion and gastrointestinal activity. Exogenous secretin, with a half-life of 4.1 notulen, metabolic clearance rate of 15 ml / min / kg body weight.
