Teduglutid acetat CAS:287714-30-1

Teduglutid je glukagonu podoben peptid-2 (GLP-2) analogni. Sestavljen je iz 33 aminokislin in je izdelan z uporabo seva Escherichia coli, modificiranega s tehnologijo rekombinantne DNA. Teduglutid se od GLP-2 razlikuje po eni aminokislini (alanin je nadomeščen z glicinom). Pomen te zamenjave je, da teduglutid deluje dlje kot endogeni GLP-2, saj je bolj odporen na proteolizo iz dipeptidil peptidaze-4.. FDA approved on December 21, 2012.

Teduglutide is an analog of naturally occurring human glucagon-like peptide-2 (GLP-2), a peptide secreted by L-cells of the distal intestine in response to meals. GLP-2 increases intestinal and portal blood flow and inhibit gastric acid secretion. Teduglutide binds to the glucagon-like peptide-2 receptors located in enteroendocrine cells, subepithelial myofibroblasts and enteric neurons of the submucosal and myenteric plexus. This causes the release of insulin-like growth factor (IGF)-1, nitric oxide and keratinocyte growth factor (KGF). These growth factors may contribute to the increase in crypt cell growth and surface area of the gastric mucosa. Konec koncev, absorption through the intestine is enhanced.