Acetato de teduglutida CAS:287714-30-1

La teduglutida es un péptido 2 similar al glucagón (GLP-2) término análogo. Esta compuesto de 33 aminoácidos y se fabrica utilizando una cepa de Escherichia coli modificada mediante tecnología de ADN recombinante. La teduglutida se diferencia del GLP-2 en un aminoácido (La alanina se sustituye por glicina.). La importancia de esta sustitución es que la teduglutida actúa durante más tiempo que el GLP-2 endógeno, ya que es más resistente a la proteólisis de la dipeptidil peptidasa-4.. FDA approved on December 21, 2012.

Teduglutide is an analog of naturally occurring human glucagon-like peptide-2 (GLP-2), a peptide secreted by L-cells of the distal intestine in response to meals. GLP-2 increases intestinal and portal blood flow and inhibit gastric acid secretion. Teduglutide binds to the glucagon-like peptide-2 receptors located in enteroendocrine cells, subepithelial myofibroblasts and enteric neurons of the submucosal and myenteric plexus. This causes the release of insulin-like growth factor (IGF)-1, nitric oxide and keratinocyte growth factor (KGF). These growth factors may contribute to the increase in crypt cell growth and surface area of the gastric mucosa. Al final, absorption through the intestine is enhanced.