Androstenedione CAS:63-05-8

Androstenedione communis est praecursor hormones sexus masculini et feminini. Quidam androstenedione etiam in plasmate secretus est, et convertantur in texturis periphericis ad testosteronem et estrogens.

Androstenedione duobus modis summari potest. Via prima involvit conversionem 17-hydroxypregnenolonis ad dehydroepiandrosterone per modum lyase 17,20, with subsequent conversion ofdehydroepiandrosterone to androstenedione via the enzyme 3-β-hydroxysteroid dehydrogenase. The secondary pathway involves conversion of 17-hydroxyprogesterone, most often a precursor to cortisol, to androstenedione directly by way of 17,20-lyase. Sic, 17,20-lyase is required for the synthesis of androstenedione, whether immediately or one step removed.

The production of adrenal androstenedione is governed by ACTH, whereas production of gonadal androstenedione is under control by gonadotropins. In premenopausal women, the adrenal glands and ovaries each produce about half of the total androstenedione(about 3 mg/diei). After menopause, androstenedione production is about halved, due primarily to the reduction of the steroid secreted by the ovary. tamen, androstenedione principale est steroides productus ab ovario postmenopausali.