製品名: Goserelin
同義語: ゴセレリン酢酸塩;(D-BE(TBU)6,アザグリ10)-ゴナドトロピン放出ホルモン酢酸塩;(D-BE(TBU)6,アザグリ10)-LHRH酢酸塩;(D-BE(TBU)6,アザグリ10)-黄体形成ホルモン放出因子酢酸塩;(D-BE(TBU)6,アザグリ10)-黄体形成ホルモン放出ホルモン酢酸塩;PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZAGLY-NH2酢酸塩;2-(アミノカルボニル)ヒドラジド;decapeptidei
CAS: 65807-02-5
MF: C61H88N18O16
MW: 1329.46
Goserelin is an analog of luteinizing hormone-releasing hormone (LHRH) useful in the treatment of malignancies responsive to hormonal manipulation. Administered parenterally in a biodegradable depot, goserelin is reportedly as effective as orchidectomy and oophorectomy in patients with advanced prostate carcinoma and pre-menopausal breast cancer.
1. ゴナドレリンはゴナドトロピン放出ホルモンの別名です (GnRH). 固相ペプチド合成法を用いて調製された合成デカペプチドです。. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary.
2. GnRHはゴナドレリン塩酸塩として入手可能です )および注射用ゴナドレリン二酢酸四水和物. Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. 獣医学でも嚢胞性卵巣疾患の牛の治療薬として使用されています。.
3. Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens.
男性
Palliative treatment of advanced carcinoma of the prostate; in combination with flutamide for management of locally confined stage T2b to T4 (stage B2 to C) carcinoma of the prostate.
女性 (3.6 mg only)
Palliative treatment of advanced breast cancer in pre- and perimenopausal women; treatment of endometriosis; as an endometrial thinning agent prior to endometrial ablation for dysfunctional uterine bleeding.
