Ürün Adı: Goserelin
Eş anlamlılar: GOSERELIN ASETAT TUZU;(D-BE(TBU)6,AZAGLY10)-GONADOTROPİN SAĞLAYAN HORMON ASETAT TUZU;(D-BE(TBU)6,AZAGLY10)-LHRH ASETAT TUZU;(D-BE(TBU)6,AZAGLY10)-LUTEİNİZAN HORMON SALGILAYAN FAKTÖRLÜ ASETAT TUZU;(D-BE(TBU)6,AZAGLY10)-LUTEİNLEYİCİ HORMON SALGILAYAN HORMON ASETAT TUZU;PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZAGLY-NH2 ASETAT TUZU;2-(aminokarbonil)hidrazit;decapeptidei
CAS: 65807-02-5
MF: C61H88N18O16
MW: 1329.46
Goserelin is an analog of luteinizing hormone-releasing hormone (LHRH) useful in the treatment of malignancies responsive to hormonal manipulation. Administered parenterally in a biodegradable depot, goserelin is reportedly as effective as orchidectomy and oophorectomy in patients with advanced prostate carcinoma and pre-menopausal breast cancer.
1. Gonadorelin gonadotropin salgılayan hormonun diğer adıdır (GnRH). Katı faz peptid sentezi kullanılarak hazırlanan sentetik bir dekapeptittir.. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary.
2. GnRH gonadorelin hidroklorür olarak mevcuttur )ve enjekte edilebilir kullanım için gonadorelin diasetat tetrahidrat. Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. Ayrıca veteriner hekimlikte kistik yumurtalık hastalığı olan sığırların tedavisinde de kullanılır..
3. Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens.
Erkekler
Palliative treatment of advanced carcinoma of the prostate; in combination with flutamide for management of locally confined stage T2b to T4 (stage B2 to C) carcinoma of the prostate.
Kadınlar (3.6 mg only)
Palliative treatment of advanced breast cancer in pre- and perimenopausal women; treatment of endometriosis; as an endometrial thinning agent prior to endometrial ablation for dysfunctional uterine bleeding.
