Product Name: Goserelin
Synonyma: GOSERELIN ACETATE SALIO;(D-BE(TBU)6,AZAGLY10)-GONADOTROPIN-MISSIO HORMONE ACETATE SALIO;(D-BE(TBU)6,AZAGLY10)-LHRH ACETATE SALIO;(D-BE(TBU)6,AZAGLY10)-LUTEINIZING hormone solvens factor ACETATE SALIO;(D-BE(TBU)6,AZAGLY10)-LUTEINIZING HORMONE ACETATE HORMONE SAL;PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZAGLY-NH2 ACETATE SALT;2-(aminocarbonyl)hydrazide;decapeptidei
CAS: 65807-02-5
MF: C61H88N18O16
MW: 1329.46
Goserelin is an analog of luteinizing hormone-releasing hormone (LHRH) useful in the treatment of malignancies responsive to hormonal manipulation. Administered parenterally in a biodegradable depot, goserelin is reportedly as effective as orchidectomy and oophorectomy in patients with advanced prostate carcinoma and pre-menopausal breast cancer.
1. Gonadorelin aliud nomen est gonadotropin-hormona solvens (GnRH). Est synthetica decapeptidis praeparata utens synthesi solidi periodi peptidis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary.
2. GnRH est available ut gonadorelin hydrochloride )et gonadorelin diacetat tetrahydratum ad usum injectibilem. Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. Usus est etiam in VETERINARIUS medicina pro curatione pecoris cum morbo ovario cystico.
3. Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens.
Men
Palliative treatment of advanced carcinoma of the prostate; in combination with flutamide for management of locally confined stage T2b to T4 (stage B2 to C) carcinoma of the prostate.
Mulieres (3.6 mg only)
Palliative treatment of advanced breast cancer in pre- and perimenopausal women; treatment of endometriosis; as an endometrial thinning agent prior to endometrial ablation for dysfunctional uterine bleeding.
