Produktname: Goserelin
Synonyme: GOSERELINACETATSALZ;(D-BE(TBU)6,AZAGLY10)-GONADOTROPIN-FREISETZENDES HORMONEACETATSALZ;(D-BE(TBU)6,AZAGLY10)-LHRH-ACETAT-SALZ;(D-BE(TBU)6,AZAGLY10)-Acetatsalz mit luteinisierendem Hormon-freisetzendem Faktor;(D-BE(TBU)6,AZAGLY10)-LUTEINISIERENDES HORMON-FREISETZENDES HORMONEACETAT-SALZ;PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZAGLY-NH2 ACETATSALZ;2-(Aminocarbonyl)Hydrazid;decapeptidei
CAS: 65807-02-5
MF: C61H88N18O16
MW: 1329.46
Goserelin is an analog of luteinizing hormone-releasing hormone (LHRH) useful in the treatment of malignancies responsive to hormonal manipulation. Administered parenterally in a biodegradable depot, goserelin is reportedly as effective as orchidectomy and oophorectomy in patients with advanced prostate carcinoma and pre-menopausal breast cancer.
1. Gonadorelin ist ein anderer Name für Gonadotropin-Releasing-Hormon (GnRH). Es handelt sich um ein synthetisches Decapeptid, das mithilfe der Festphasenpeptidsynthese hergestellt wird. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary.
2. GnRH ist als Gonadorelinhydrochlorid erhältlich )und Gonadorelindiacetat-Tetrahydrat zur injizierbaren Anwendung. Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. Es wird auch in der Veterinärmedizin zur Behandlung von Rindern mit zystischer Ovarialerkrankung eingesetzt.
3. Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens.
Männer
Palliative treatment of advanced carcinoma of the prostate; in combination with flutamide for management of locally confined stage T2b to T4 (stage B2 to C) carcinoma of the prostate.
Frauen (3.6 mg only)
Palliative treatment of advanced breast cancer in pre- and perimenopausal women; treatment of endometriosis; as an endometrial thinning agent prior to endometrial ablation for dysfunctional uterine bleeding.
